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KMID : 0605620130200030091
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Journal of Korean Society of Biological Psychiatry
2013 Volume.20 No. 3 p.91 ~ p.96
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Association Study between Treatment Response of Amisulpride and Dopamine D3 Receptor Gene Polymorphisms
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Kang Seung-Gul
Lee Heon-Jeong
Lee Seung-Jae
Choi Tae-Young
Woo Jung-Min
Kim Ji-Hyun
Jung Sung-Won
Koo Bon-Hoon
Lee Kwang-Hun
Kim Jeong-Lan
Chee Ik-Seung
Lee Jong-Hun
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Abstract
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Objectives: The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride.
Methods: After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.
Results: There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and non-responders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (χ2 = 5.23, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score.
Conclusions: This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.
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KEYWORD
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Treatment response, Amisulpride, DRD3 gene, Polymorphisms, rs6280
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